New Embryonic Stem Cell Lines Avoid Animal Products

Researchers at Stanford University School of Medicine derived new human embryonic stem cell lines using minimal animal products. Although numerous groups have derived stem cell lines, most were generated in the presence of animal serum and animal-derived feeder cells. These animal products are a concern because they may cause the stem cells to produce an immune response when transplanted into humans and may induce biological changes especially to the genome. In this study, the team characterized six lines that were derived with minimal use of animal products.  The researchers verified that the lines behave like normal ES cells in their ability to both self-renew and differentiate to the major cell types.  These lines may be useful for future studies that help move the field toward clinical-grade cell therapy.

Stem Cells and Development: June 17, 2008
CIRM funding: Renee Reijo Pera (RC1-00137)

Related Information: Stanford Stem Cell Biology and  Regenerative Medicine Institute, Pera lab page

Key Protein Involved in Forming Nuclear Membrane after Division Found

Researchers at UC, San Diego found the function of a key protein involved in the cell cycle, the process by which a cell duplicates all its genes and divides. The protein is critical to the assembly of the membrane around the cell's nucleus. A fundamental understanding of the cell cycle is integral to advancing all cell-based therapies.

Proceedings of the National Academy of Sciences: April 17, 2007
CIRM funding: Youngjun Kim (T1-00003)

Related Information: UCSD Stem Cell Initiative