High school students get stem cell experience in California labs

UC Davis interns Rex Reyes, Jaskaran Dhillon, Thomas Gepts and Kalani Ratnasiri

Last week CIRM gathered together the Creativity Award interns to learn about their summer projects. These high school students came from UC Davis, UC San Francisco, UC Santa Barbara and Stanford to congregate at the Children's Hospital Oakland, home of CIRM board member Bert Lubin.



The goal of the awards was to give high school students experience in research labs, and to encourage those students to think broadly about science with the idea that novel therapies will come from creative thinking. The students all carried out additional projects in humanities or other areas of science. (We blogged about the program here.)



The students I met were incredible, and I'm apparently not the only person to think so. Charlie Casey at UC Davis did a story about the program quoting Jan Nolta, who directs the school's Institute for Regenerative Cures.

“These students truly exceeded our expectations,” said Jan Nolta, director of the UCD Institute for Regenerative Cures and a mentor for several of the students. “One of our other interns was so determined to learn about stem cell science that he traveled two hours from Vallejo and back each day to work in our Sacramento lab.

“All of these young people performed fabulously, and they represent a very bright future for science, particularly, I hope, in stem cell research.”

The Sacramento Bee wrote about the four UC Davis interns.

Program directors selected the students based on their award-winning presentations of biotechnology concepts on websites they designed for UCD's 2011 Teen Biotech Challenge.



The four took a course in the procedures and techniques of stem cell production with master's-degree students from California State University, Sacramento, and worked on individual projects with scientist mentors.

When I talked to Gerhard Bauer, who taught that master's-level course, he said the high school students held their own among those more senior students. It'll be a while before we know where these students end up. For now, it's exciting to see high school students—many from lower socioeconomic homes—get excited about college and about the potential for stem cell research.



A.A.

UC Davis scientist on a quest for cures in the cleanest of labs

Gerhard Bauer in the UC Davis GMP facility

One of the real thrills of working at CIRM is talking to the researchers who are so excited about finding new therapies. As part of our lunchtime talk series, today we heard from Gerhard Bauer of UC Davis. The only thing more exciting to Bauer than new therapies is the thought of having those therapies come out of his beautiful new GMP lab.

A GMP (Good Manufacturing Practice) lab is a clean facility that can be used to process the cells and other products that might one day go in people. When you see photos of scientists in white suits looking through microscopes, they’re likely in a GMP facility. If the lab sparkles so brightly you need sunglasses to look at the photos, it’s probably one of Bauer’s six GMP labs he’s built since moving from Austria to the U.S. in the 1980s to work on HIV/AIDS. He’s like the MacGyver of GMP labs. Nothing already manufactured was quite perfect enough for his facility, so in his spare time, you know, when he wasn’t running a lab and picking paint colors for the building, he also designed better GMP equipment.

Do I sound smitten? My apologies. I do aim for professional disinterest, but I am only human and I also really, really want to see therapies for some of the diseases they are tackling in that facility. It’s inspiring to see such enthusiasm in the people who are working toward those cures. Among the many diseases under investigation in the facility (Huntington’s disease, peripheral artery disease, bone fractures, liver disease) Bauer is part of the Stanford Disease Team working toward a therapy for the horrific childhood skin disorder epidermolysis bullosa. He and other members of that team recently spoke about the work at a governing board meeting. Videos of those talks are available here, but be warned that the disease is awful and the images are graphic. Personally, I can’t look.

One fun thing we learned is that Bauer has been taking on CIRM Bridges interns and training them in GMP procedures (here's a video about the Bridges program if you aren't familiar with it). He’s hired one, and has another working in the lab now. That’s exactly what we were hoping for in the Bridges program. Undergrad or masters students are learning stem cell science and getting trained for jobs in California’s expanding stem cell biology sector.

The lunch talks are a great opportunity for CIRM staff to hear about how those disease teams are progressing and to understand the challenges. Getting to a cure isn’t easy. One thing we all learned from Bauer’s talk is that whatever therapy the team comes up with, it’s going to be absolutely, totally, completely GMP certified. And clean? It’s going to be clean. Because when Bauer wasn’t dreaming up better lab equipment he was also certifying the cleaning protocols.

Here’s a video we made last year about the GMP facility:



- A.A.